Lithium Hydroxide → HCID 69427262, compound

Participants

Reaction Steps

To a solution of Cis-N-(1-Benzoyl-2-methyl-1,2,3,4-tetrahydroquinolin-4-yl)-N-phenyl-malonamic acid methyl ester (0.031 g) in a mixture of methanol (1 ml) and water (1 ml), 0.0067 g of lithium hydroxide was added under stirring at room temperature, over night. In order to complete the reaction, 0.0067 g of lithium hydroxide was added and the mixture was stirred over night. Then dichloromethane and an aqueous solution of sodium bicarbonate were added, the organic layer was separated, dried over sodium sulfate, the solvent was removed under reduce pressure to give a solid which was purified by flash chromatography with dichloromethane/methanol (95/5) as eluent to give a solid (0.01 g, 33.3% yield).

Provenance & Evidence