Triphenylphosphine → HCID 178501381, compound

Participants

Role	Name	HCID	Charge
Reactant	Triphenylphosphine	HCID 11776	—
Reactant	3,5-Dimethyl-4-(hydroxymethyl)isoxazole	HCID 289575	—
Reactant	Diethyl azodicarboxylate	HCID 5462977	—
Reactant	HCID 178501373	HCID 178501373	—
Solvent	Tetrahydrofuran	HCID 8028	—
Product	HCID 178501381	HCID 178501381	—

Reaction Conditions

Temperature	5 °C

Reaction Steps

(3,5-Dimethylisoxazol-4-yl)methanol (0.28 g, 1.5 mmol), methyl (2S)-2-[(1,1-dioxo-1,2-benzoisothiazol-3-yl)amino]-3-(4-hydroxyphenyl)propionate (0.36 g, 1 mmol) and triphenylphosphine (0.79 g, 3 mmol) were dissolved in tetrahydrofuran (2 ml). After cooling to 5° C., DEAD (0.52 g, 3 mmol) was added to the reaction mixture. The reaction was then stirred at room temperature for 18–24 h. THF was evaporated to obtain crude title product.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07220766B2
Source dataset	uspto-grants-2007_05
ORD ID	ord-a17195e243cc4d33be3e4516f81a5079
Source note	uspto-grants-2007_05