反应详情

A solution of 5,6-dichloro-2-(4-cyano-2-methoxyphenyl)benzimidazole, prepared as described in Preparation 5, in ethanol (50 ml) and 2N NaOH (15 ml) was refluxed for 16 h. Solvent was removed under reduced pressure and the residue was acidified with 37% HCl (10 ml), stirred for 1 h. The solid was filtered, washed with water (50 ml), dried at 50° C. under vacuum to give 0.92 g of the title compound (yield 46%), mp>250° C.

1. customSolvent was removed under reduced pressure
2. filtrationThe solid was filtered
3. washwashed with water (50 ml)
4. customdried at 50° C. under vacuum