HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1352730Generated: November 3, 2026
Ethyl Acetate → 2-(4-Methyl-1-piperazinyl)-4-quinolineacetamide
https://huagongshe.com/reaction/1352730
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | 1-Methylpiperazine | HCID 53167 | — |
| Reactant | 2-Chloro-4-quinolineacetamide | HCID 18770875 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | 2-(4-Methyl-1-piperazinyl)-4-quinolineacetamide | HCID 18770861 | — |
Reaction Steps
2-(2-chloro-quinolin-4-yl)-acetamide (500 mg, 2.27 mmol) is dissolved in 1-methyl-2-pyrrolidinone (3.0 mL). N-methylpiperazin (1.3 mL, 5 eq.) is added and the reaction is stirred at 80° C. for 48 h. AcOEt (20 mL) is added and the precipitate is purified by FCC (AcOEVEtOH/28% NH4OH 80:18:1) to afford 2-[2-(4-methyl-piperazin-1-yl)-quinolin-4-yl]-acetamide as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07220774B2 |
|---|
| Source dataset | uspto-grants-2007_05 |
|---|
| ORD ID | ord-3e553389dad9414e8fcf81fa1fb75ccd |
|---|
| Source note | uspto-grants-2007_05 |
|---|
