Thionyl Chloride → 4-(3-Chloro-4-methoxybenzylamino)-5-chloroformyl-6-chloro-2-methylthiopyrimidine

HRID 1352794Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1352794
[Cl:1][C:2]1[CH:3]=[C:4]([CH:19]=[CH:20][C:21]=1[O:22][CH3:23])[CH2:5][NH:6][C:7]1[C:12]([C:13](O)=[O:14])=[C:11]([Cl:16])[N:10]=[C:9]([S:17][CH3:18])[N:8]=1.S(Cl)([Cl:26])=O>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:19]=[CH:20][C:21]=1[O:22][CH3:23])[CH2:5][NH:6][C:7]1[C:12]([C:13]([Cl:26])=[O:14])=[C:11]([Cl:16])[N:10]=[C:9]([S:17][CH3:18])[N:8]=1

Komponenten

3

Edukt 2

HCID 24386Thionyl Chloride2×HCID 178482684-(3-Chloro-4-methoxybenzylamino)-5-carboxy-6-chloro-2-methylthiopyrimidine

Produkt 1

HCID 178482834-(3-Chloro-4-methoxybenzylamino)-5-chloroformyl-6-chloro-2-methylthiopyrimidine

Reaktionsbedingungen

Temperatur
75 °C

Versuchsvorschrift

A mixture of 4-(3-chloro-4-methoxybenzylamino)-5-carboxy-6-chloro-2-methylthiopyrimidine 10.50 g and thionyl chloride 25 ml is stirred for 20 minutes at 75° C. After reaction thionyl chloride is distilled off and the solvent is removed by azeotrope with methylene chloride to give 4-(3-chloro-4-methoxybenzylamino)-5-chloroformyl-6-chloro-2-methylthiopyrimidine.

Aufarbeitung

  1. distillationis distilled off
  2. customthe solvent is removed by azeotrope with methylene chloride

Quellen und Nachweise

ORD-Eintrag
ord-6a58b8bf060848999592de0358b5314b
Quelldatensatz
uspto-grants-2007_05
Patentnummer
US07220736B2

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