L-Prolinol → HCID 17848353, compound

HRID 1352797Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]([CH:28]=[CH:29][C:30]=1[O:31][CH3:32])[CH2:5][NH:6][C:7]1[C:12]([C:13](=[O:22])[NH:14][CH2:15][C:16]2[N:21]=[CH:20][CH:19]=[CH:18][N:17]=2)=[C:11]([O:23][CH3:24])[N:10]=[C:9](S(C)=O)[N:8]=1.[NH:33]1[CH2:39][CH2:38][CH2:37][C@H:34]1[CH2:35][OH:36]>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:28]=[CH:29][C:30]=1[O:31][CH3:32])[CH2:5][NH:6][C:7]1[C:12]([C:13](=[O:22])[NH:14][CH2:15][C:16]2[N:21]=[CH:20][CH:19]=[CH:18][N:17]=2)=[C:11]([O:23][CH3:24])[N:10]=[C:9]([N:33]2[CH2:39][CH2:38][CH2:37][CH:34]2[CH2:35][OH:36])[N:8]=1

Participants

Reactant 2

HCID 640091L-Prolinol

HCID 17848271HCID 17848271, compound

Product 1

HCID 17848353HCID 17848353, compound

Procedure

4-(3-Chloro-4-methoxybenzylamino)-5-[N-(2-pyrimidinylmethyl)carbamoyl]-6-methoxy-2-methylsulfinylpyrimidine (prepared in the above (4)) and L-prolinol is treated in the same manner as Example 321(5) to give 4-(3-chloro-4-methoxybenzylamino)-5-[N-(2-pyrimidinylmethyl)carbamoyl]-6-methoxy-2-(2-hydroxymethyl-1-pyrrolodinyl)pyrimidine as a colorless crystalline powder 88 mg. mp 153–154° C.

Workup

additionis treated in the same manner as Example 321(5)

Sources & evidence

ORD record: ord-c42d2c97cae449b8ade73f293e135398
Source dataset: uspto-grants-2007_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07220736B2

Reaction notes

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