Diethyl 5-[(diethoxyphosphinyl)methyl]-1,3-benzenedicarboxylate → 5-(Phosphonomethyl)isophthalic acid

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A solution of diethyl 5-[(diethoxyphosphinyl) methyl]-1,3-benzenedicarboxylate (0.186 g, 0.5 mmol) in 12 N HCl (2.5 mL) was heated at 100° C. for 24 hours. The resulting precipitate was washed with water and dried under vacuum to give 0.057 g of white powder: 1H NMR (D2O) δ 3.11 (d, 2H), 7.93 (s, 2H), 8.19 (s, 1H). TLC: Rf 0.20 (EtOAc/Hexanes 1/1). Elemental analysis calculated for C9H7O7P.H2O: C, 38.86; H, 3.99. Found: C, 38.74; H, 4.08.

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