Potassium Carbonate → HCID 22928719, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of the compound (180 mg, 0.567 mmol) of Example 6-2 in N,N-dimethylformamide (3.0 ml) was added potassium carbonate (100 mg, 0.724 mmol) and ethyl 4-bromo-n-bytyrate (105 mg, 0.538 mmol), and the mixture was stirred for 2 hours at 45° C. To the reaction mixture was further added ethyl 4-bromo-n-butyrate (20.0 mg, 0.100 mmol) and the mixture was stirred for additional 9 hours at 50° C. Thereto was added an aqueous sodium hydrogencarbonate solution and the mixture was extracted with ethyl acetate. The organic layer was washed with an aqueous saturated sodium chloride solution, and dried over magnesium sulfate. The solvent was removed under reduced pressure. The residue was purified with silica gel chromatography (hexane:ethyl acetate=4:1) to give the subject compound (199 mg, 81%).

Provenance & Evidence