HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1352901Generated: November 1, 2026
1-Bromo-4-fluorobenzene → HCID 86587736, compound
https://huagongshe.com/reaction/1352901
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-Bromo-4-fluorobenzene | HCID 9993 | — |
| Reactant | HCID 68563369 | HCID 68563369 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 86587736 | HCID 86587736 | 41.4% |
Reaction Steps
A mixture of N4-(3-methoxyphenyl)-N6,N6-dimethyl-2-(1-piperazinyl)-4,6-pyrimidinediamine (36 mg, 0.1 mmol), 1-bromo-4-fluorobenzene (20 mg, 0.13 mmol) was heated at 100° C. for 1 h. The crude product was dissolved in CH2Cl2 (0.5 mL) and purified by preparative TLC using 5% methanol in EtOAc, giving the desired product (20 mg, 40%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07220775B2 |
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| Source dataset | uspto-grants-2007_05 |
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| ORD ID | ord-5f1093e0bad944e49b51ef41b9ae15b9 |
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| Source note | uspto-grants-2007_05 |
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