HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1352912Generated: November 1, 2026
3-(Trifluoromethyl)aniline → HCID 178468887, compound
https://huagongshe.com/reaction/1352912
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3-(Trifluoromethyl)aniline | HCID 7375 | — |
| Reactant | HCID 4331211 | HCID 4331211 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | HCID 178468887 | HCID 178468887 | 23% |
Reaction Steps
A mixture of ethyl 5-[(2,3-dioxo-2,3-dihydro-1H-indol-1-yl)methyl]-2-furoate (60 mg, 0.200 mmol) and 3-trifluoromethylaniline (32 mg, 0.200 mmol) was heated at 140° C. for 2 h. The residue was dissolved in CHCl3 (1 mL) and purified by preparative TLC using EtOAc/hexane (6:4), giving the desired product (20 mg, 23%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07220775B2 |
|---|
| Source dataset | uspto-grants-2007_05 |
|---|
| ORD ID | ord-7c59d8d8ea2a43e3843be666241d5825 |
|---|
| Source note | uspto-grants-2007_05 |
|---|
