Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1,3-Benzenedicarboxylic acid, 5-hydroxy-, 1,3-dimethyl ester | HCID 83065 | — |
| Reactant | HCID 21101477 | HCID 21101477 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 86210898 | HCID 86210898 | — |
Reaction Steps
5-(6-Azidohexoxy)isophthalic Acid Dimethyl Ester was prepared as follows: A mixture of dimethyl 5-hydroxyisophthalate 4 (1.05 g, 5 mmol), 6-azido-1-(p-toluenesulfonyloxy)hexane (1.57 g, 5 mmol) and K2CO3 (1.38 g, 10 mmol) in DMF (15 mL) was stirred for 17 h at 80° C. After cooling down, H2O (150 mL) was added and the mixture was extracted with EtOAc, washed with water, dried (MgSO4), and the solvent was evaporated off. The pure title compound was obtained as a colorless oil (1.51 g, 90%) after column chromatography (SiO2: CH2Cl2).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07220818B2 |
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| Source dataset | uspto-grants-2007_05 |
|---|
| ORD ID | ord-2448631c931140bda76e6b696f24f348 |
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| Source note | uspto-grants-2007_05 |
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