HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → Ethyl 3-allyloxycarbonylamino-3-(3-aminophenyl)-propionate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Stannous Chloride | HCID 24479 | — |
| Reactant | Ethyl 3-allyloxycarbonylamino-3-(3-nitrophenyl)-propionate | HCID 21101502 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Ethyl 3-allyloxycarbonylamino-3-(3-aminophenyl)-propionate | HCID 21101501 | — |
Reaction Steps
Tin(II) chloride (64.6 g) was added to a solution of ethyl 3-allyloxycarbonylamino-3-(3-nitrophenyl)-propionate from II.1c (18.8 g) in 245 ml of ethanol, and the reaction mixture was heated under reflux for 2 h. After cooling the solution, it was adjusted to pH=7 using 2N NaOH, briefly heated, cooled again and filtered. It was then extracted with dichloromethane, and the org. phase was dried (MgSO4) and concentrated. 10.9 g of product were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07220824B1 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-327cddf2a9414ccfa73b9ec2c93723bb |
| Source note | uspto-grants-2007_05 |