HuagongsheHuagongshe Chemistry Print Report · For research reference only
Stannous Chloride → HCID 21101496, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Stannous Chloride | HCID 24479 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | HCID 20745454 | HCID 20745454 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 21101496 | HCID 21101496 | — |
Reaction Steps
A solution of ethyl 3-{2-[(3-(nitro)benzoyl)amino]acetamido}-3-phenyl-propanoate from II.3a (2.7 g) in 100 ml of ethanol was treated with Tin(II) chloride (7.6 g) and heated under reflux for 3 h. The reaction mixture was then added to ice, rendered neutral with NaHCO3 solution and filtered through Celite. The filtrate was extracted with methylene chloride, dried (MgSO4) and concentrated. Chromatographic purification (purification (methylene chloride/methanol (5:1)) yielded the product (yield: 2.0 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07220824B1 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-4c8aa8842e9d4762badfa525e7fb0c74 |
| Source note | uspto-grants-2007_05 |