1,8-Diazabicyclo(5.4.0)undec-7-ene → HCID 17989327, compound

Participants

Reaction Steps

2-Amino-N-[3-methoxy-4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-4-phenoxy-benzamide [Example C1] (62 mg, 0.14 mmol) was dissolved in dichloromethane (5 ml) and treated with carbonyl diimidazole (50 mg, 0.31 mmol) and DBU (0.1 ml). The mixture was stirred for 4 h at RT then the solvent removed and the residue purified by flash chromatography on silica gel (eluting with ammonia-methanol-dichloromethane) to obtain the title compound;

Provenance & Evidence