Butyl nitrite → HCID 21101400, compound

Participants

Reaction Steps

A solution of the free base of this amine (58 mg, 0.13 mmol) in dichloromethane (2 ml) was acidified with 5 drops of TFA then treated with butyl nitrite (100 ul). A deep orange colour formed immediately. After 1 minute, DBU was introduced dropwise until basic. The solvent was removed in vacuo and the residue purified by flash chromatography on silica gel (eluting with methanol-dichloromethane-aqueous ammonia) to give the title compound which crystallised as a pale yellow HCl salt on treatment with 1M HCl in ether;

Provenance & Evidence