4-Phenoxy-2-benzofuran-1,3-dione → HCID 17989354, compound

HRID 1353094Notes

Reaction equation

HRID 1353094 reaction equation
[N:1]1([CH2:6][CH:7]2[CH2:16][CH2:15][C:14]3[CH:13]=[C:12]([NH2:17])[CH:11]=[CH:10][C:9]=3[CH2:8]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[O:18]([C:25]1[CH:35]=[CH:34][CH:33]=[C:27]2[C:28]([O:30]C(=O)[C:26]=12)=O)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1.C(N(C(C)C)C[CH2:41][O:42]C1C=CC(N)=CC=1OC)(C)C>>[O:18]([C:25]1[CH:26]=[C:27]2[C:33](=[CH:34][CH:35]=1)[C:41](=[O:42])[N:17]([C:12]1[CH:11]=[CH:10][C:9]3[CH2:8][CH:7]([CH2:6][N:1]4[CH2:5][CH2:4][CH2:3][CH2:2]4)[CH2:16][CH2:15][C:14]=3[CH:13]=1)[C:28]2=[O:30])[C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1

Participants

4

Reactant 3

HCID 123803714-Phenoxy-2-benzofuran-1,3-dioneHCID 186726014-{2-[Di(propan-2-yl)amino]ethoxy}-3-methoxyanilineHCID 21940075HCID 21940075, compound

Product 1

HCID 17989354HCID 17989354, compound

Procedure

6-Pyrrolidin-1-ylmethyl-5,6,7,8-tetrahydro-naphthalen-2-ylamine [WO 0121577 A2] was treated with 3-phenoxyphthalic anhydride in the same manner as for 4-(2-diisopropylamino-ethoxy)-3-methoxy-phenylamine in Example A4 to give the title compound.

Sources & evidence

ORD record
ord-229546a8b9e2488fb2b780e758846831
Source dataset
uspto-grants-2007_05
Patent number
US07220777B2

Reaction notes

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