Hydrazine hydrate (1:1) → 3-Fluoro-4-(4-methylpiperazin-1-yl)benzene-1,2-diamine

Participants

Reaction Steps

Hydrazine monohydrate (0.13 mL, 2.7 mmol) was added to a solution of phthalimide 1 (134 mg, 0.39 mmol) in ethanol (4 mL). The reaction was maintained overnight at rt and then was filtered through Celite. The filter cake was rinse with EtOAc (3×) and the organic portions were combined and concentrated to give diamine 2 which was carried forward without further purification: LCMS m/z 215.1 (MH+), tR=1.77 min.

Provenance & Evidence