Potassium Phosphate, Tribasic → HCID 69374561, compound

Participants

Reaction Steps

3.0 g of (+) ethyl 2-(2,4-dichloro-3-nitro-5-fluorobenzoyl)-3-[(1-acetoxyprop-2(S)-yl)amino]acrylate was dissolved in 15 ml of acetonitrile under heating to 75˜80° C. 2.12 g (1.5 eq.) of K3PO4 was added in portions to the reaction mixture, which was then stirred at the same temperature for 1.5 hours. The reaction mixture was filtered under a reduced pressure and washed with 60 ml of dichloromethane. The filtrate was concentrated under a reduced pressure. The resulting residue was dissolved in 50 ml of dichloromethane and then washed with water. The organic layer was concentrated under a reduced pressure to give 2.64 g of (−) ethyl N-(acetoxy-prop-2(S)-yl)-6-fluoro-7-chloro-8-nitro-4-quinolone-3-carboxylate (Yield: 95.7%)

Provenance & Evidence