HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pentafluoropyridine → 2,3,5,6-Tetrafluoropyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pentafluoropyridine | HCID 69690 | — |
| Catalyst | Zinc | HCID 23994 | — |
| Solvent | Ammonia | HCID 222 | — |
| Product | 2,3,5,6-Tetrafluoropyridine | HCID 137749 | 84.5% |
Reaction Steps
80 g of pentafluoropyridine (Janssen) and 111.5 g of zinc power were added to 560 ml of 20% aqueous ammonia. The resulting mixture was stirred at room temperature for 5 hours, and then gently refluxed to remove water using a Dean-Stark trap, to obtain 60.4 g (yield: 84.5%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07220863B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-3fb78612de14466d8d0354fdf46a2fe2 |
| Source note | uspto-grants-2007_05 |