3-Chloro-2,4,5,6-tetrafluoropyridine → 3-Chloro-2,5,6-trifluoropyridine

Participants

Reaction Steps

55.5 g of 3-chloro-2,4,5,6-tetrafluoropyridine (Fluorochem) and 20 g of zinc powder were added to 560 ml of 20% aqueous ammonia, and the resulting mixture was stirred at room temperature for 5 hours. The reaction mixture was refluxed while removing water using a Dean-Stark trap, to obtain 46.2 g of the title compound.

Provenance & Evidence