HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 5-Chloro-2,3-difluoropyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | HCID 21102306 | HCID 21102306 | — |
| Catalyst | Copper Sulfate | HCID 24462 | — |
| Solvent | Water | HCID 962 | — |
| Product | 5-Chloro-2,3-difluoropyridine | HCID 2783248 | 86.5% |
Reaction Steps
17.9 g of the compound obtained in Step 2 was added to a mixture of 360 ml of acetic acid and 135 ml of water, and 450 ml of 10% aqueous copper sulfate was added dropwise thereto. The resulting mixture was refluxed for 24 hours while removing water using a Dean-Stark trap, to obtain 12.9 g of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07220863B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-6785ea2635d9448d861381c92336438c |
| Source note | uspto-grants-2007_05 |