反应详情

Charged in a hydrogenation reactor were 100 ml of methanol, 16.1 g of the compound obtained in Step 4 and 8.13 g of Raney nickel catalyst, and H2 gas was introduced therein. The reactor was kept at room temperature for 12 hours, and the reaction mixture was filtered through Cellite® to remove the catalyst. The filtrate was concentrated under a reduced pressure to obtain 12.7 g of the title compound as a solid (purity: 98.5%).

1. additionCharged in a hydrogenation reactor
2. additionwas introduced
3. filtrationthe reaction mixture was filtered through Cellite®
4. customto remove the catalyst
5. concentrationThe filtrate was concentrated under a reduced pressure