5-Chloro-3-fluoro-2-hydrazinylpyridine → 2-Amino-5-chloro-3-fluoropyridine

Charged in a hydrogenation reactor were 100 ml of methanol, 16.1 g of the compound obtained in Step 4 and 8.13 g of Raney nickel catalyst, and H2 gas was introduced therein. The reactor was kept at room temperature for 12 hours, and the reaction mixture was filtered through Cellite® to remove the catalyst. The filtrate was concentrated under a reduced pressure to obtain 12.7 g of the title compound as a solid (purity: 98.5%).

1. additionCharged in a hydrogenation reactor
2. additionwas introduced
3. filtrationthe reaction mixture was filtered through Cellite®
4. customto remove the catalyst
5. concentrationThe filtrate was concentrated under a reduced pressure

ORD record

ord-a49653627ec9489a90d1b385dcd789dd

Source dataset

uspto-grants-2007_05

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07220863B2