反应详情

Charged in a hydrogenation reactor were 100 ml of methanol, 16.3 g of the compound obtained in Step 2 of Example 1 and 8.0 g of Raney nickel catalyst, and H2 gas was introduced therein, followed by allowing the reduction to proceed at room temperature for 12 hours. The reaction mixture was filtered through Cellite® to remove the catalyst. The filtrate was concentrated under a reduced pressure to obtain 13.7 g of the title compound as a solid (purity: 99.1%).

1. additionCharged in a hydrogenation reactor
2. additionwas introduced
3. filtrationThe reaction mixture was filtered through Cellite®
4. customto remove the catalyst
5. concentrationThe filtrate was concentrated under a reduced pressure