Water → HCID 10161403, compound

Participants

Reaction Conditions

Reaction Steps

To a mixed solution of the compound (1.20 g) prepared in Example 3 in ethyl acetate (12 ml) and dimethylsulfoxide (5.0 ml), diisopropylethylamine (2.7 ml) was added, and a dimethylsulfoxide (6.5 ml) solution of sulfur trioxide-pyridine complex (1.25 g) was added dropwise thereto at −10° C., followed by stirring at −10° C. for 2 hours. The reaction mixture was poured into cold water, and extracted with ethyl acetate. The extract was washed with a saturated saline, dried with anhydrous magnesium sulfate, and concentrated to thereby obtain the crude title compound (1.57 g) having the following physical data. The obtained compound was used without purification in the subsequent reaction.

Provenance & Evidence