Sodium Hydroxide → HCID 11169884, compound

Participants

Reaction Steps

To a solution of (E)(E)(S)(S) 2-ethoxy-3-{4-[3-(4′-{3-[4-(2-ethoxy-2-ethoxycarbonyl-ethyl)-phenoxy]-1-methyl-propenyl}-biphenyl-4-yl)-but-2-enyloxy]-phenyl}-propionic acid ethyl ester (example 11) (367 mg 0.5 mmol) in ethanol (10 mL) was added 1N sodium hydroxide (2 mL). The reaction mixture was stirred at room temperature for 18 h, and at 60° C. 1 h. The resulting mixture was diluted with water and ethyl acetate, the aqueous layer collected and further extracted with ethyl acetate (3×). The organic layers were combined, washed with brine, dried (MgSO4) and evaporated to give 180 mg (53%) of the title compound.

Provenance & Evidence