Sodium Hydroxide → HCID 86588419, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (E)(E)(S)(S) 2-ethoxy-3-{4-[5-(7-{5-[4-(2-ethoxy-2-ethoxycarbonyl-ethyl)-phenoxy]-3-methyl-pent-3-en-1-ynyl}-9-oxo-9H-fluoren-2-yl)-3-methyl-pent-2-en-4-ynyloxy]-phenyl}-propionic acid ethyl ester (example 13) (185 mg, 0.23 mmol) in ethanol (10 mL) was added 1N sodium hydroxide (2.3 mL). After stirring at 60° C. for 30 min., the reaction mixture was concentrated in vacuo, added water and 1N hydrochloride acid to pH 1. The product was extracted with dichloromethane (×3) and the combined organic phases were dried (MgSO4), filtered and concentrated in vacuo to give 160 mg of the title compound as a crystalline product.

Provenance & Evidence