Hydrochloric Acid → HCID 21102435, compound

Participants

Reaction Steps

To a solution of [4-(3-{3-[3-(4-methoxycarbonylmethyl-phenoxy)-prop-1-ynyl]-phenyl}-prop-2-ynyloxy)-phenyl]-acetic acid methyl ester (example 15) (200 mg, 0.42 mmol) in ethanol (3 mL) was added 1N sodium hydroxide (1.6 mmol, 1.6 mL). After stirring at room temperature for 16 h, the reaction mixture was added 1N hydrochloride acid to pH 1. The product was isolated by filtration and dried to give 100 mg (53%) of the title compound as a crystalline product.

Provenance & Evidence