HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl ethoxyacetate → Ethyl 3-[4-(benzyloxy)phenyl]-2-ethoxy-3-hydroxypropanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl ethoxyacetate | HCID 69955 | — |
| Reactant | Benzaldehyde, 4-(phenylmethoxy)- | HCID 78109 | — |
| Reactant | Lithium diisopropylamide | HCID 2724682 | — |
| Reactant | 3-(3-Benzyloxy-phenyl)-3-hydroxy-2-methoxy-propionic acid methyl ester | HCID 58822694 | — |
| Product | Ethyl 3-[4-(benzyloxy)phenyl]-2-ethoxy-3-hydroxypropanoate | HCID 58822578 | — |
Reaction Steps
The title compound was prepared from 4-benzyloxybenzaldehyde, lithium diisopropylamide and ethyl 2-ethoxyacetate via the same procedure used for the preparation of 3-(3-benzyloxy-phenyl)-3-hydroxy-2-methoxy propionic acid methyl ester (example 9, step 1). MS (ES) for C20H24O5 [M+H2O—H]+: 327, [M+Na]+: 367.4.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07220880B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-918fac85f2c54c1aab43d2d292314656 |
| Source note | uspto-grants-2007_05 |