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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1353211Generated: October 25, 2026

tert-Butyl 2-bromo-2-methylpropionate → (2S)-3-[4-(1-tert-butoxycarbonyl-1-methyl-ethoxy)-phenyl]-2-methoxy-propionic acid ethyl ester

https://huagongshe.com/reaction/1353211

Reaction equation

Participants

RoleNameHCIDCharge
Reactanttert-Butyl 2-bromo-2-methylpropionateHCID 90290—
Reactant(2S)-3-(4-tert-butoxycarbonylmethoxy-phenyl)-2-methoxy-propionic acid ethyl esterHCID 58864672—
Product(2S)-3-[4-(1-tert-butoxycarbonyl-1-methyl-ethoxy)-phenyl]-2-methoxy-propionic acid ethyl esterHCID 58646618—

Reaction Steps

The title compound was prepared from (2S)-3-(4-hydroxy-phenyl)-2-methoxy-propionic acid ester (Preparation 1) and 2-bromo-2-methyl-propionic acid tert-butyl ester via the same procedure used to prepare (2S)-3-(4-tert-butoxycarbonylmethoxy-phenyl)-2-methoxy-propionic acid ethyl ester (example 121, step 1) to produce a yellow oil.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07220880B2
Source datasetuspto-grants-2007_05
ORD IDord-8ec324b82fd049f0b9baf0d4eb873fd0
Source noteuspto-grants-2007_05