1-Heptanamine → (2S)-2-methoxy-3-[4-(1-methyl-1-octylcarbamoyl-ethoxy)-phenyl]-propionic acid

HRID 1353213ノート

反応式

HRID 1353213 の反応式
C([O:3][C:4](=[O:22])[C@@H:5]([O:20][CH3:21])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][C:14]([C:17]([OH:19])=O)([CH3:16])[CH3:15])=[CH:9][CH:8]=1)C.C(N)CCCCCC.C(O[C@@H](CC1C=CC(O[C@@H](C(=O)[NH:49][CH2:50][CH2:51][C:52]2[CH:57]=[CH:56][C:55](OC3C=CC=CC=3)=[CH:54][CH:53]=2)C)=CC=1)C(O)=O)C>>[CH3:21][O:20][C@@H:5]([CH2:6][C:7]1[CH:8]=[CH:9][C:10]([O:13][C:14]([CH3:15])([C:17](=[O:19])[NH:49][CH2:50][CH2:51][CH2:52][CH2:53][CH2:54][CH2:55][CH2:56][CH3:57])[CH3:16])=[CH:11][CH:12]=1)[C:4]([OH:3])=[O:22]

参加物

4

反応物 3

HCID 81271-HeptanamineHCID 9847886(2S,1R)-2-ethoxy-3-(4-{1-[2-(4-phenoxy-phenyl)-ethylcarbamoyl]-ethoxy}-phenyl)propionic acidHCID 58646603(2S)-3-[4-(1-carboxy-1-methyl-ethoxy)-phenyl]-2-methoxy-propionic acid ethyl ester

生成物 1

HCID 58646593(2S)-2-methoxy-3-[4-(1-methyl-1-octylcarbamoyl-ethoxy)-phenyl]-propionic acid

実験手順

The title compound was prepared from (2S)-3-[4-(1-carboxy-1-methyl-ethoxy)-phenyl]-2-methoxy-propionic acid ethyl ester (PREPARATION 5, step 2) and heptylamine via the same procedure used for the preparation of (2S, 1R)-2-ethoxy-3-(4-{1-[2-(4-phenoxy-phenyl)-ethylcarbamoyl]-ethoxy}-phenyl)-propionic acid (Example 1, step 3) to produce a colorless oil. MS (ES) for C21H33NO5 [M+H]+: 380.

後処理

  1. customto produce a colorless oil

出典と根拠

ORDレコード
ord-40c73c2b6686490da5bc943f3d66ef64
出典データセット
uspto-grants-2007_05
特許番号
US07220880B2

反応ノート

読み込み中…