(2S,1R)-2-ethoxy-3-(4-{1-[2-(4-phenoxy-phenyl)-ethylcarbamoyl]-ethoxy}-phenyl)propionic acid → HCID 58646634, compound

HRID 1353224Notes

Reaction equation

HRID 1353224 reaction equation
C(O[C:4](=O)[C@@H:5](OC)[CH2:6][C:7]1[CH:12]=[CH:11][C:10](OCC(O)=O)=[CH:9][CH:8]=1)C.[CH2:21]([O:23][C@@H:24]([CH2:28][C:29]1[CH:34]=[CH:33][C:32]([O:35][C@@H:36]([C:38](=[O:55])[NH:39][CH2:40][CH2:41]C2C=CC(OC3C=CC=CC=3)=CC=2)C)=[CH:31][CH:30]=1)[C:25]([OH:27])=[O:26])C>>[C:7]1([CH:6]([C:5]2[CH:4]=[CH:7][CH:6]=[CH:5][CH:4]=2)[CH2:41][CH2:40][NH:39][C:38]([CH2:36][O:35][C:32]2[CH:31]=[CH:30][C:29]([CH2:28][C@H:24]([O:23][CH3:21])[C:25]([OH:27])=[O:26])=[CH:34][CH:33]=2)=[O:55])[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=1

Participants

3

Reactant 2

HCID 9847886(2S,1R)-2-ethoxy-3-(4-{1-[2-(4-phenoxy-phenyl)-ethylcarbamoyl]-ethoxy}-phenyl)propionic acidHCID 58864673(2S)-3-(4-carboxymethoxy-phenyl)-2-methoxy-propionic acid ethyl ester

Product 1

HCID 58646634HCID 58646634, compound

Procedure

The title compound was prepared from (2S)-3-(4-carboxymethoxy-phenyl)-2-methoxy-propionic acid ethyl ester (PREPARATION 3, step 2) and 3,3-eiphenyl-propylamine via the same procedure used for the preparation of (2S,1R)-2-ethoxy-3-(4-{1-[2-(4-phenoxy-phenyl)-ethylcarbamoyl]-ethoxy}-phenyl)-propionic acid (Example 1, step 3) to produce a yellow oil. MS (ES) for C27H29NO5 [M+H]+: 448.

Workup

  1. customto produce a yellow oil

Sources & evidence

ORD record
ord-3e05394c518b45958d06763927fd6ba8
Source dataset
uspto-grants-2007_05
Patent number
US07220880B2

Reaction notes

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