HuagongsheHuagongshe Chemistry Print Report · For research reference only
(4-Aminophenoxy)benzene → 2-Methoxy-3-{3-[(4-phenoxy-phenylcarbamoyl)-methoxy]-phenyl}-propionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (4-Aminophenoxy)benzene | HCID 8764 | — |
| Reactant | (2S,1R)-2-ethoxy-3-(4-{1-[2-(4-phenoxy-phenyl)-ethylcarbamoyl]-ethoxy}-phenyl)propionic acid | HCID 9847886 | — |
| Reactant | 3-(3-Carboxymethoxy-phenyl)-2-methoxy-propionic acid methyl ester | HCID 58646610 | — |
| Product | 2-Methoxy-3-{3-[(4-phenoxy-phenylcarbamoyl)-methoxy]-phenyl}-propionic acid | HCID 23132720 | — |
Reaction Steps
The title compound was prepared from 3-(3-carboxymethoxy-phenyl)-2-methoxy-propionic acid methyl ester (PREPARATION 4, step 2) and 4-phenoxy-phenylamine via the same procedure used for the preparation of (2S,1R)-2-ethoxy-3-(4-{1-[2-(4-phenoxy-phenyl)-ethylcarbamoyl]-ethoxy}-phenyl)-propionic acid (Example 1, step 3) to produce a colorless oil. MS (ES) for C24H23NO6 [M+H]+: 322.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07220880B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-f8c917702a194c6fbfa033d6f307fab8 |
| Source note | uspto-grants-2007_05 |