(2S)-3-[4-(1-tert-butoxycarbonyl-1-methyl-ethoxy)-phenyl]-2-ethoxy-propionic acid ethyl ester → (2S)-3-[4-(1-carboxy-1-methyl-ethoxy)-phenyl]-2-ethoxy-propionic acid ethyl ester

HRID 1353239Notes

Reaction equation

HRID 1353239 reaction equation
[CH2:1]([O:3][C:4](=[O:27])[C@@H:5]([O:24][CH2:25][CH3:26])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][C:14]([C:17]([O:19]C(C)(C)C)=[O:18])([CH3:16])[CH3:15])=[CH:9][CH:8]=1)[CH3:2].C(OC(=O)[C@@H](OC)CC1C=CC(OCC(O)=O)=CC=1)C>>[CH2:1]([O:3][C:4](=[O:27])[C@@H:5]([O:24][CH2:25][CH3:26])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][C:14]([C:17]([OH:19])=[O:18])([CH3:15])[CH3:16])=[CH:9][CH:8]=1)[CH3:2]

Participants

3

Reactant 2

HCID 58646647(2S)-3-[4-(1-tert-butoxycarbonyl-1-methyl-ethoxy)-phenyl]-2-ethoxy-propionic acid ethyl esterHCID 58864673(2S)-3-(4-carboxymethoxy-phenyl)-2-methoxy-propionic acid ethyl ester

Product 1

HCID 58646608(2S)-3-[4-(1-carboxy-1-methyl-ethoxy)-phenyl]-2-ethoxy-propionic acid ethyl ester

Procedure

The title compound was prepared from (2S)-3-[4-(1-tert-butoxycarbonyl-1-methyl-ethoxy)-phenyl]-2-ethoxy-propionic acid ethyl ester (EXAMPLE 49, step 1) via the same procedure used to prepare (2S)-3-(4-carboxymethoxy-phenyl)-2-methoxy-propionic acid ethyl ester (PREPARATION 3, step 2) to produce a yellow oil.

Workup

  1. customto produce a yellow oil

Sources & evidence

ORD record
ord-2ce733b6b4184beaa531057fe6e70954
Source dataset
uspto-grants-2007_05
Patent number
US07220880B2

Reaction notes

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