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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1353248Generated: November 1, 2026

4-Ethylphenethylamine → (2S)-3-(3-{1-[2-(4-ethyl-phenyl)-ethylcarbamoyl]-1-methyl-ethoxy}-phenyl)-2-methoxy-propionic acid

https://huagongshe.com/reaction/1353248

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-EthylphenethylamineHCID 144047—
Reactant(2S,1R)-2-ethoxy-3-(4-{1-[2-(4-phenoxy-phenyl)-ethylcarbamoyl]-ethoxy}-phenyl)propionic acidHCID 9847886—
ReactantHCID 58646552HCID 58646552—
Product(2S)-3-(3-{1-[2-(4-ethyl-phenyl)-ethylcarbamoyl]-1-methyl-ethoxy}-phenyl)-2-methoxy-propionic acidHCID 58646578—

Reaction Steps

The title compound was prepared from (2S)-3-[3-(1-carboxy-1-methyl-ethoxy)-phenyl]-2-methoxy-propionic acid methyl ester (EXAMPLE 56, step 2) and 2-(4-ethyl-phenyl)-ethylamine via the same procedure used for the preparation of (2S,1R)-2-ethoxy-3-(4-{1-[2-(4-phenoxy-phenyl)-ethylcarbamoyl]-ethoxy}-phenyl)-propionic acid (Example 1, step 3) to produce a colorless oil. MS (ES) for C24H31NO5 [M−H]−: 412.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07220880B2
Source datasetuspto-grants-2007_05
ORD IDord-9db063c61b4c40b6a7525412ad4049ed
Source noteuspto-grants-2007_05