HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Heptanamine → (2S)-3-[3-(1-heptylcarbamoyl-1-methyl-ethoxy)-phenyl]-2-methoxy-propionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Heptanamine | HCID 8127 | — |
| Reactant | (2S,1R)-2-ethoxy-3-(4-{1-[2-(4-phenoxy-phenyl)-ethylcarbamoyl]-ethoxy}-phenyl)propionic acid | HCID 9847886 | — |
| Reactant | HCID 58646552 | HCID 58646552 | — |
| Product | (2S)-3-[3-(1-heptylcarbamoyl-1-methyl-ethoxy)-phenyl]-2-methoxy-propionic acid | HCID 58646640 | — |
Reaction Steps
The title compound was prepared from (2S)-3-[3-(1-carboxy-1-methyl-ethoxy)-phenyl]-2-methoxy-propionic acid methyl ester (EXAMPLE 56, step 2) and heptylamine via the same procedure used for the preparation of (2S,1R)-2-ethoxy-3-(4-{1-[2-(4-phenoxy-phenyl)-ethylcarbamoyl]-ethoxy}-phenyl)-propionic acid (Example 1, step 3) to produce a colorless oil. MS (ES) for C21H33NO5 [M+H]+: 480.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07220880B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-d5249c022b5d492cb8b0c4fc711bc068 |
| Source note | uspto-grants-2007_05 |