Cyclopentylamine → HCID 69420478, compound

HRID 1353299Notes

Reaction equation

HRID 1353299 reaction equation
C(OC(=O)[C@@H](OC)CC1C=CC(OCC(O)=O)=CC=1)C.C1(N)CCCC1.[CH2:27]([O:29][C@@H:30]([CH2:34][C:35]1[CH:40]=[CH:39][C:38]([O:41][C@@H:42]([C:44](=[O:61])[NH:45][CH2:46][CH2:47][C:48]2[CH:53]=[CH:52]C(OC3C=CC=CC=3)=CC=2)C)=[CH:37][CH:36]=1)[C:31]([OH:33])=[O:32])C>>[CH:46]1([NH:45][C:44]([CH2:42][O:41][C:38]2[CH:37]=[CH:36][C:35]([CH2:34][C@H:30]([O:29][CH3:27])[C:31]([OH:33])=[O:32])=[CH:40][CH:39]=2)=[O:61])[CH2:47][CH2:48][CH2:53][CH2:52]1

Participants

4

Reactant 3

HCID 2906CyclopentylamineHCID 9847886(2S,1R)-2-ethoxy-3-(4-{1-[2-(4-phenoxy-phenyl)-ethylcarbamoyl]-ethoxy}-phenyl)propionic acidHCID 58864673(2S)-3-(4-carboxymethoxy-phenyl)-2-methoxy-propionic acid ethyl ester

Product 1

HCID 69420478HCID 69420478, compound

Procedure

The title compound was prepared from (2S)-3-(4-carboxymethoxy-phenyl)-2-methoxy-propionic acid ethyl ester (PREPARATION 3, step 2) and cyclopentylamine via the same procedure used for the preparation of (2S,1R)-2-ethoxy-3-(4-{1-[2-(4-phenoxy-phenyl)-ethylcarbamoyl]-ethoxy}-phenyl)-propionic acid (Example 1, step 3) to produce a colorless oil. MS (ES) for C17H23NO5 [M−H]−: 320.

Workup

  1. customto produce a colorless oil

Sources & evidence

ORD record
ord-3f52a16ab6664be1907c3edd4301cede
Source dataset
uspto-grants-2007_05
Patent number
US07220880B2

Reaction notes

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