Buthidazolamine → HCID 58646639, compound

HRID 1353302Notes

Reaction equation

HRID 1353302 reaction equation
C([O:3][C:4](=[O:20])[C@@H:5]([O:18][CH3:19])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][C:15]([OH:17])=O)=[CH:9][CH:8]=1)C.[C:21]([C:25]1[S:29][C:28]([NH2:30])=[N:27][N:26]=1)([CH3:24])([CH3:23])[CH3:22].C(O[C@@H](CC1C=CC(O[C@@H](C(=O)NCCC2C=CC(OC3C=CC=CC=3)=CC=2)C)=CC=1)C(O)=O)C>>[C:21]([C:25]1[S:29][C:28]([NH:30][C:15]([CH2:14][O:13][C:10]2[CH:9]=[CH:8][C:7]([CH2:6][C@H:5]([O:18][CH3:19])[C:4]([OH:3])=[O:20])=[CH:12][CH:11]=2)=[O:17])=[N:27][N:26]=1)([CH3:24])([CH3:23])[CH3:22]

Participants

4

Reactant 3

HCID 170170ButhidazolamineHCID 9847886(2S,1R)-2-ethoxy-3-(4-{1-[2-(4-phenoxy-phenyl)-ethylcarbamoyl]-ethoxy}-phenyl)propionic acidHCID 58864673(2S)-3-(4-carboxymethoxy-phenyl)-2-methoxy-propionic acid ethyl ester

Product 1

HCID 58646639HCID 58646639, compound

Procedure

The title compound was prepared from (2S)-3-(4-carboxymethoxy-phenyl)-2-methoxy-propionic acid ethyl ester (PREPARATION 3, step 2) and 5-tert-butyl-[1,3,4]thiadiazol-2-ylamine via the same procedure used for the preparation of (2S,1R)-2-ethoxy-3-(4-{1-[2-(4-phenoxy-phenyl)-ethylcarbamoyl]-ethoxy}-phenyl)-propionic acid (Example 1, step 3) to produce a colorless oil. MS (ES) for C18H23N3O5S [M−H]−: 392.

Workup

  1. customto produce a colorless oil

Sources & evidence

ORD record
ord-a226a5fea70745749bf48712a90cfd55
Source dataset
uspto-grants-2007_05
Patent number
US07220880B2

Reaction notes

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