Hexylamine → HCID 58646628, compound

HRID 1353304Notes

Reaction equation

HRID 1353304 reaction equation
C(OC(=O)[C@@H](OC)CC1C=CC(OCC(O)=O)=CC=1)C.C(N)CCCCC.[CH2:28]([O:30][C@@H:31]([CH2:35][C:36]1[CH:41]=[CH:40][C:39]([O:42][C@@H:43]([C:45](=[O:62])[NH:46][CH2:47][CH2:48][C:49]2C=C[C:52](OC3C=CC=CC=3)=[CH:51][CH:50]=2)C)=[CH:38][CH:37]=1)[C:32]([OH:34])=[O:33])C>>[CH2:47]([NH:46][C:45]([CH2:43][O:42][C:39]1[CH:40]=[CH:41][C:36]([CH2:35][C@H:31]([O:30][CH3:28])[C:32]([OH:34])=[O:33])=[CH:37][CH:38]=1)=[O:62])[CH2:48][CH2:49][CH2:50][CH2:51][CH3:52]

Participants

4

Reactant 3

HCID 8102HexylamineHCID 9847886(2S,1R)-2-ethoxy-3-(4-{1-[2-(4-phenoxy-phenyl)-ethylcarbamoyl]-ethoxy}-phenyl)propionic acidHCID 58864673(2S)-3-(4-carboxymethoxy-phenyl)-2-methoxy-propionic acid ethyl ester

Product 1

HCID 58646628HCID 58646628, compound

Procedure

The title compound was prepared from (2S)-3-(4-carboxymethoxy-phenyl)-2-methoxy-propionic acid ethyl ester (PREPARATION 3, step 2) and hexylamine via the same procedure used for the preparation of (2S,1R)-2-Ethoxy-3-(4-{1-[2-(4-phenoxy-phenyl)-ethylcarbamoyl]-ethoxy}-phenyl)-propionic acid (Example 1, step 3) to produce a colorless oil. MS (ES) for C18H27NO5 [M−H]−: 338.

Workup

  1. customto produce a colorless oil

Sources & evidence

ORD record
ord-f9b713240cd14ff08d8a6e73e092b30b
Source dataset
uspto-grants-2007_05
Patent number
US07220880B2

Reaction notes

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