1-Heptanamine → HCID 58646569, compound

HRID 1353305Notes

Reaction equation

HRID 1353305 reaction equation
C(OC(=O)[C@@H](OC)CC1C=CC(OCC(O)=O)=CC=1)C.C(N)CCCCCC.[CH2:29]([O:31][C@@H:32]([CH2:36][C:37]1[CH:42]=[CH:41][C:40]([O:43][C@@H:44]([C:46](=[O:63])[NH:47][CH2:48][CH2:49][C:50]2C=[CH:54][C:53](OC3C=CC=CC=3)=[CH:52][CH:51]=2)C)=[CH:39][CH:38]=1)[C:33]([OH:35])=[O:34])C>>[CH2:48]([NH:47][C:46]([CH2:44][O:43][C:40]1[CH:41]=[CH:42][C:37]([CH2:36][C@H:32]([O:31][CH3:29])[C:33]([OH:35])=[O:34])=[CH:38][CH:39]=1)=[O:63])[CH2:49][CH2:50][CH2:51][CH2:52][CH2:53][CH3:54]

Participants

4

Reactant 3

HCID 81271-HeptanamineHCID 9847886(2S,1R)-2-ethoxy-3-(4-{1-[2-(4-phenoxy-phenyl)-ethylcarbamoyl]-ethoxy}-phenyl)propionic acidHCID 58864673(2S)-3-(4-carboxymethoxy-phenyl)-2-methoxy-propionic acid ethyl ester

Product 1

HCID 58646569HCID 58646569, compound

Procedure

The title compound was prepared from (2S)-3-(4-carboxymethoxy-phenyl)-2-methoxy-propionic acid ethyl ester (PREPARATION 3, step 2) and heptylamine via the same procedure used for the preparation of (2S,1R)-2-ethoxy-3-(4-{1-[2-(4-phenoxy-phenyl)-ethylcarbamoyl]-ethoxy}-phenyl)-propionic acid (Example 1, step 3) to produce a colorless oil. MS (ES) for C19H29NO5 [M−H]−: 352.

Workup

  1. customto produce a colorless oil

Sources & evidence

ORD record
ord-111c9ab81f144517beaaa7397835ab23
Source dataset
uspto-grants-2007_05
Patent number
US07220880B2

Reaction notes

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