HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → HCID 21101958, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| Reactant | 4,7-dichloro-2-methylquinoline | HCID 854747 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 21101958 | HCID 21101958 | 47.3% |
Reaction Steps
4,7-Dichloro-2-methylquinoline (De, D., Byers L. D., Krogstad, D. J. J. Heterocyclic Chem. 1997, 34, 315) (453 mg, 2.1 mmol) and 1-tert-butoxycarbonylpiperazine (2.05 g, 11.0 mmol) are reacted according to method A. The Boc group is cleaved with trifluoroacetic acid (5 mL) in CH2Cl2 (5 mL) giving 0.26 g of the piperazine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07220856B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-7d3f96daa4df44c0bfbe5d45386a6044 |
| Source note | uspto-grants-2007_05 |