4-Fluorophenyl isocyanate → HCID 21101782, compound

Participants

Reaction Steps

7-Chloro-2-methyl-4-(piperazin-1-yl)quinoline (0.26 g), 4-fluorophenyl isocyanate (114 μL, 1.0 mmol), and DMAP (2 mg) in THF (10 mL) are reacted according to method C yielding the product as a colorless solid after column chromatography with hexane-EtOAc. 1H NMR ([D]6-DMSO), δ 2.58 (s, 3H), 3.17 (m, 4H), 3.71 (m, 4H), 6.94 (s, 1H), 7.06 (t, 2H), 7.46 (m, 3H), 7.87 (d, 1H), 8.01 (d, 1H), 8.68 (br. s, 1H).

Provenance & Evidence