Trifluoroacetic acid → HCID 21101955, compound

Participants

Reaction Steps

4,5-Dichloro-2-methylquinoline, obtained by treating 5-chloro-2-methyl-4-quinolone with POCl3 (cf. De, D., Byers L. D., Krogstad, D. J. J. Heterocyclic Chem. 1997, 34, 315; 1H NMR (CDCl3), δ 2.68 (s, 3H), 7.41 (s, 1H), 7.55 (t, 1H), 7.59 (dd, 1H), 7.95 (dd, 1H)), (125 mg, 0.59 mmol) and 1-tert-butoxycarbonylpiperazine (559 mg, 3.0 mmol) are reacted according to method A. The Boc group is cleaved with trifluoroacetic acid (3 mL) in CH2Cl2 (5 mL) giving 0.18 g of the piperazine.

Provenance & Evidence