HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-[4-(4-Fluorophenylaminocarbonyl)piperazin-1-yl]-7-nitroquinolin trifluoroacetate → 7-Amino-4-[4-(4-fluorophenylaminocarbonyl)piperazin-1-yl]quinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-[4-(4-Fluorophenylaminocarbonyl)piperazin-1-yl]-7-nitroquinolin trifluoroacetate | HCID 21101694 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 7-Amino-4-[4-(4-fluorophenylaminocarbonyl)piperazin-1-yl]quinoline | HCID 21101741 | — |
Reaction Steps
A suspension of 4-[4-(4-fluorophenylaminocarbonyl)piperazin-1-yl]-7-nitroquinoline trifluoroacetate (130 mg) and 10% Pd/C (20 mg) in MeOH is stirred in a hydrogen atmosphere for 30 min. The reaction mixture is filtered and concentrated giving the title product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07220856B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-551c8c35c7ba464fa68793cde9b2539c |
| Source note | uspto-grants-2007_05 |