tert-Butanol → HCID 21101591, compound

Participants

Reaction Steps

A solution of 7-chloro-4-[4-(4-fluorophenylaminocarbonyl)piperazin-1-yl]quinoline-2-carboxylic acid (215 mg, 0.5 mmol), diphenylphosphoryl azide (DPPA, 144 μL, 0.65 mmol), and triethylamine (92 μL, 0.65 mmol) in t-butanol (5 mL) is heated at 105° C. in an Ar atmosphere for 3 h. The solvent is removed, and the residue is dissolved in EtOAc, washed with water, dried (MgSO4), and concentrated. Purification by column chromatography with CH2Cl2-MeOH affords the title product.

Provenance & Evidence