Acetyl chloride → HCID 21101584, compound

Participants

Reaction Steps

2-tert-Butoxycarbonylamino-7-chloro-4-[4-(4-fluorophenylaminocarbonyl)piperazin-1-yl]quinoline (110 mg, 0.22 mmol) in CH2Cl2 (1 mL) is treated with trifluoroacetic acid (1 mL) for 2 h at room temp. The reaction mixture is concentrated. The residue is dissolved in CH2Cl2 (9 mL). Triethylamine (154 μL, 1.1 mmol), acetyl chloride (26 μL, 0.24 mmol), and DMAP (10 mg) are added. The reaction mixture is stirred at room temp. for 3 h, washed with water, dried (MgSO4), and concentrated. Purification of the residue by column chromatography with CH2Cl2-MeOH affords the title product.

Provenance & Evidence