HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenyl isocyanate → HCID 21101816, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenyl isocyanate | HCID 7672 | — |
| Reactant | HCID 21101585 | HCID 21101585 | — |
| Solvent | Acetonitrile 1,2-dichloroethane | HCID 22402149 | — |
| Product | HCID 21101816 | HCID 21101816 | — |
Reaction Steps
To a solution of 2-amino-7-chloro-4-[4-(4-fluorophenylaminocarbonyl)piperazin-1-yl]quinoline (20 mg, 0.05 mmol) in MeCN-1,2-dichloroethane 1:1 (12 mL) is added phenyl isocyanate (17 μL, 0.11 mmol). The reaction mixture is heated at reflux for 1 h. Upon cooling the title product precipitates and is collected by filtration.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07220856B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-8471f25505d1497bbb10b486a17d7877 |
| Source note | uspto-grants-2007_05 |