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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1353345Generated: October 31, 2026

Trifluoroacetic acid → HCID 21101779, compound

https://huagongshe.com/reaction/1353345

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrifluoroacetic acidHCID 6422—
ReactantHCID 21101703HCID 21101703—
SolventDichloromethaneHCID 6344—
ProductHCID 21101779HCID 21101779—

Reaction Steps

4-[4-(tert-Butoxycarbonyl)piperazin-1-yl]-7-chloro-2-(isopropylamino)quinoline (33 mg, 0.08 mmol) is deprotected with TFA in CH2Cl2 and transformed into the title product according to method C using 4-fluorophenyl isocyanate (13 μL, 0.11 mmol) and triethylamine (80 μL, 0.57 mmol) to give a colorless solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07220856B2
Source datasetuspto-grants-2007_05
ORD IDord-8457085aa9584433b969749e45bd5ddf
Source noteuspto-grants-2007_05