HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 7-Chloro-4-[4-(4-fluorophenylaminocarbonyl)-2-methylpiperazin-1-yl]quinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 4-Fluorophenyl isocyanate | HCID 70955 | — |
| Reactant | 4-[4-(tert-Butoxycarbonyl)-2-methylpiperazin-1-yl]-7-chloroquinoline | HCID 21101700 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 7-Chloro-4-[4-(4-fluorophenylaminocarbonyl)-2-methylpiperazin-1-yl]quinoline | HCID 21101771 | — |
Reaction Steps
4-[4-(tert-butoxycarbonyl)-2-methylpiperazin-1-yl]-7-chloroquinoline (0.30 g, 0.8 mmol) is deprotected with TFA in CH2Cl2 and transformed after being washed with base into the product according to method C using 4-fluorophenyl isocyanate (61 μL, 0.54 mmol) to give the title product a colorless solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07220856B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-fe80b26363ca4a799245101af8c52490 |
| Source note | uspto-grants-2007_05 |