HuagongsheHuagongshe Chemistry Print Report · For research reference only
4,7-Dichloroquinoline → 7-Chloro-4-(2,5-diazanorborn-2-yl)quinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4,7-Dichloroquinoline | HCID 6866 | — |
| Reactant | Dabco | HCID 9237 | — |
| Reactant | 2,5-Diazabicyclo[2.2.1]heptane dihydrobromide | HCID 16213147 | — |
| Reactant | Dichloromethane methanol | HCID 21226129 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Product | 7-Chloro-4-(2,5-diazanorborn-2-yl)quinoline | HCID 21101959 | — |
Reaction Steps
4,7-Dichloroquinoline (0.38 g, 1.9 mmol) and 2,5-diazanorbornane dihydrobromide (1.0 g, 3.8 mmol), and DABCO (1.3 g, 11.4 mmol) in n-butanol (20 mL) are reacted according to method B yielding the product after column chromatography with CH2Cl2-MeOH.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07220856B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-db71e1ba5cca4d6fb728f947868bd64e |
| Source note | uspto-grants-2007_05 |