HuagongsheHuagongshe Chemistry Print Report · For research reference only
7-Chloro-4-(piperazin-1-yl)quinoline → 7-Chloro-4-[4-(3,4-difluorophenylaminocarbonyl)piperazin-1-yl]quinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 7-Chloro-4-(piperazin-1-yl)quinoline | HCID 738389 | — |
| Reactant | 3,4-Difluorophenyl isocyanate | HCID 2734708 | — |
| Reactant | Ethyl acetate hexane | HCID 21226206 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 7-Chloro-4-[4-(3,4-difluorophenylaminocarbonyl)piperazin-1-yl]quinoline | HCID 21101762 | — |
Reaction Steps
7-Chloro-4-(piperazin-1-yl)quinoline (0.16 g, 0.65 mmol) and 3,4-difluorophenyl isocyanate (76 μL, 0.65 mmol) in THF (10 mL) are reacted according to method C yielding the title product as a colorless foam after column chromatography with hexane-EtOAc.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07220856B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-002734f2b38147448f485034a9f8a25a |
| Source note | uspto-grants-2007_05 |